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NBC chose Leno over Letterman, and Letterman left the network for CBS, where his new late-night show would go head-to-head with Leno''.

Despite initially struggling in the ratings (he was renewed at 13-week intervals until he proved himself), O' Brien persevered with his own style of off-center, self-effacing comedy, reminiscent of Letterman's early days, when he was establishing himself as a favorite of college students and the Generation X crowd.

He has three brothers: Neal, an antique car collector; Luke, a lawyer and Justin, a business consultant, and two sisters: Kate, a teacher; and Jane, a scriptwriter.

Actor and comedian Denis Leary is his cousin.; the writing staff of the show won an Emmy for Outstanding Writing in 1989.

The way you care about people comes through in every single story you report.'Her co-host also thanked her for all the good work she did on the show and insisted it was not goodbye.